Innovation Sphere

Projects Sharing Researchers


  • Devesh Misra
  • Alok Kumar
  • Krishna Nune



Project TitleLiving Implant for Bone Regeneration
Track Code2016-049
Short Description

The University of Texas at El Paso seeks a partner for licensing a living bone replacement implant capable of promoting cellular and molecular processes of real tissue.


This invention is mixture of additive manufactured Ti-6Al-4V foams and a hydrogel matrix. This matrix can form vasculature under physiological conditions, while maintaining osteoblast cell differentiation and proliferation. This approach induces a hypoxia mimetic stress that will trigger cellular survival signals that ultimately enhances wound healing processes in bone. The high water retention capability of the hydrogel with ~97% equilibrium water content enables the delivery of cells to promote the bone tissue growth.

Tagsbone implant, injectable osteoblasts, Hydrogel, alginate, Gelatin, nanocrystalline hydroxyapatite, Ti-6Al-4V, titanium alloy scaffold
Posted DateNov 18, 2016 6:00 PM


Devesh Misra
Alok Kumar
Krishna Nune


Melissa Silverstein


  • Can easily take the shape of bone defect
  • Favorably modulate growth, proliferation, and differentiation of cells
  • Supports cell migration
  • High water retention capability of hydrogel 
  • Induces a hypoxia mimetic stress response

Potential Applications

  • Bone tissue engineering 
  • 3D printing
  • Bone defect treatment
  • Orthopedic cell therapy 
  • Bone implant technology

Contact Information

For more information, please contact UTEP's Office of Technology Commercialization at or 915-747-8030.


File Name Description
One-Pager for 2016-046 and 2016-049 None Download

Intellectual Property

Patent Number Issue Date Type Country of Filing
None None Other Patent None